DNA Methylation and Cancer Therapy

DNA Methylation and Cancer Therapy

Author: Moshe Szyf

Publisher: Springer Science & Business Media

ISBN: 9780387274430

Category: Medical

Page: 239

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NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
DNA Methylation and Cancer Therapy
Language: en
Pages: 239
Authors: Moshe Szyf
Categories: Medical
Type: BOOK - Published: 2007-04-03 - Publisher: Springer Science & Business Media

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana
DNA Methylation, Epigenetics and Metastasis
Language: en
Pages: 332
Authors: Manel Esteller
Categories: Medical
Type: BOOK - Published: 2005-06-09 - Publisher: Springer Science & Business Media

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour.
DNA Methylation and Cancer
Language: en
Pages: 170
Authors: P.A. Jones, P.K. Vogt
Categories: Medical
Type: BOOK - Published: 2000-02-25 - Publisher: Springer

This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer. Issues related to the mutagenicity of 5-methylcytosine and the increase in the interaction of chemical and physical carcinogens with these residues is discussed. The book summarizes the modulation of viral
Epigenetic Mechanisms in Cancer
Language: en
Pages: 392
Authors: Sabita Saldanha
Categories: Medical
Type: BOOK - Published: 2017-11-16 - Publisher: Academic Press

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences
Epigenetics in Cancer
Language: en
Pages: 174
Authors: Wiley
Categories: Science
Type: BOOK - Published: 2013-07-12 - Publisher: John Wiley & Sons

Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the