Fragment-based Approaches in Drug Discovery

Fragment-based Approaches in Drug Discovery

Author: Wolfgang Jahnke

Publisher: John Wiley & Sons

ISBN: 9783527608607

Category: Science

Page: 391

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This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Fragment-based Approaches in Drug Discovery
Language: en
Pages: 391
Authors: Wolfgang Jahnke, Daniel A. Erlanson
Categories: Science
Type: BOOK - Published: 2006-12-13 - Publisher: John Wiley & Sons

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on
Fragment Based Drug Design
Language: en
Pages: 645
Authors: Wolfgang Jahnke, Daniel A. Erlanson
Categories: Medical
Type: BOOK - Published: 2011-02-28 - Publisher: Academic Press

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on
Fragment-Based Drug Discovery
Language: en
Pages: 296
Authors: Edward R. Zartler, Michael Shapiro
Categories: Science
Type: BOOK - Published: 2008-11-20 - Publisher: John Wiley & Sons

Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who
Fragment-based Drug Discovery
Language: en
Pages: 528
Authors: Daniel A. Erlanson, Wolfgang Jahnke, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Categories: Medical
Type: BOOK - Published: 2016-02-23 - Publisher: John Wiley & Sons

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications
Structure-based Drug Discovery
Language: en
Pages: 250
Authors: Harren Jhoti, Andrew R. Leach
Categories: Science
Type: BOOK - Published: 2007-05-24 - Publisher: Springer Science & Business Media

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well