Fragment Based Drug Design

Fragment Based Drug Design

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Publisher: Academic Press

ISBN: 9780123812759

Category: Medical

Page: 645

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There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD
Fragment Based Drug Design
Language: en
Pages: 645
Authors:
Categories: Medical
Type: BOOK - Published: 2011-02-28 - Publisher: Academic Press

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on
Fragment-Based Drug Discovery
Language: en
Pages: 296
Authors: Edward R. Zartler, Michael Shapiro
Categories: Science
Type: BOOK - Published: 2008-11-20 - Publisher: John Wiley & Sons

Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who
Fragment-based Approaches in Drug Discovery
Language: en
Pages: 391
Authors: Wolfgang Jahnke, Daniel A. Erlanson
Categories: Science
Type: BOOK - Published: 2006-12-13 - Publisher: John Wiley & Sons

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on
Fragment-Based Drug Discovery and X-Ray Crystallography
Language: en
Pages: 228
Authors: Thomas G. Davies, Marko Hyvönen
Categories: Science
Type: BOOK - Published: 2012-01-23 - Publisher: Springer Science & Business Media

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in
Fragment-based Drug Discovery
Language: en
Pages: 528
Authors: Daniel A. Erlanson, Wolfgang Jahnke, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Categories: Medical
Type: BOOK - Published: 2016-02-23 - Publisher: John Wiley & Sons

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications