Fragment-Based Drug Discovery and X-Ray Crystallography

Fragment-Based Drug Discovery and X-Ray Crystallography

Author: Thomas G. Davies

Publisher: Springer Science & Business Media

ISBN: 9783642275401

Category: Science

Page: 228

View: 337

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Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan
Fragment-Based Drug Discovery and X-Ray Crystallography
Language: en
Pages: 228
Authors: Thomas G. Davies, Marko Hyvönen
Categories: Science
Type: BOOK - Published: 2012-01-24 - Publisher: Springer Science & Business Media

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in
Fragment Based Drug Design
Language: en
Pages: 645
Authors: Thomas G. Davies, Marko Hyvönen
Categories: Medical
Type: BOOK - Published: 2011-02-28 - Publisher: Academic Press

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on
Fragment-based Approaches in Drug Discovery
Language: en
Pages: 391
Authors: Wolfgang Jahnke, Daniel A. Erlanson
Categories: Science
Type: BOOK - Published: 2006-12-13 - Publisher: John Wiley & Sons

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on
Fragment-Based Drug Discovery
Language: en
Pages: 264
Authors: Steven Howard, Chris Abell
Categories: Medical
Type: BOOK - Published: 2015-07-03 - Publisher: Royal Society of Chemistry

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just
Fragment-Based Drug Discovery
Language: en
Pages: 296
Authors: Edward R. Zartler, Michael Shapiro
Categories: Science
Type: BOOK - Published: 2008-11-20 - Publisher: John Wiley & Sons

Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who