Genetically Engineered Mice Handbook

Genetically Engineered Mice Handbook

Author: John P. Sundberg

Publisher: CRC Press

ISBN: 9781420039078

Category: Medical

Page: 336

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While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models. The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities. This essential reference examines commonly used traditional, as well as emerging, technologies To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.
Genetically Engineered Mice Handbook
Language: en
Pages: 336
Authors: John P. Sundberg, Tsutomu Ichiki
Categories: Medical
Type: BOOK - Published: 2016-04-19 - Publisher: CRC Press

While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow
Pathology of Genetically Engineered and Other Mutant Mice
Language: en
Pages: 496
Authors: John P. Sundberg, Peter Vogel, Jerrold M. Ward
Categories: Medical
Type: BOOK - Published: 2022-01-26 - Publisher: John Wiley & Sons

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically
Genetically Engineered Mice for Cancer Research
Language: en
Pages: 632
Authors: Jeffrey E. Green, Thomas Ried
Categories: Medical
Type: BOOK - Published: 2011-12-09 - Publisher: Springer Science & Business Media

Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which
Pathology of Genetically-Engineered Mice
Language: en
Pages: 520
Authors: Jerrold M. Ward, Joel F. Mahler, Robert R. Maronpot, John Sundberg
Categories: Medical
Type: BOOK - Published: 2000-11-28 - Publisher: Wiley-Blackwell

In response to the use of genetically-enigneered mice in the biomedical research revolution in technology, this book brings together the collective expertise of many specialists to cover the approaches to organ-specific evaluations, to provide examples of many currently available mutant mice, to illustrate how specific defects can be studied, and
The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals
Language: en
Pages: 848
Authors: Robert C. Hubrecht, James Kirkwood
Categories: Medical
Type: BOOK - Published: 2010-01-19 - Publisher: John Wiley & Sons

The seminal reference on the care of laboratory and captiveanimals, The UFAW Handbook on the Care and Management ofLaboratory and Other Research Animals is a must-have for anyoneworking in this field. The UFAW Handbook has been thedefinitive text since 1947. Written for an international audience,it contains contributions from experts from