Immunological Aspects of Liver Disease

Immunological Aspects of Liver Disease

Author: Howard Thomas

Publisher: Springer

ISBN: UCAL:B4530700

Category: Medical

Page: 232

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Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .
Immunological Aspects of Liver Disease
Language: en
Pages: 232
Authors: Howard Thomas, P.A. Miescher, H.J. Mueller-Eberhard
Categories: Medical
Type: BOOK - Published: 1982-04 - Publisher: Springer

Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of
Immunological Aspects of Liver Disease
Language: en
Pages: 210
Authors: H.C. Thomas, P.A. Miescher, H.J. Mueller-Eberhard
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of
Liver Immunology
Language: en
Pages: 633
Authors: M. Eric Gershwin, John M. Vierling, Atsushi Tanaka, Michael P. Manns
Categories: Medical
Type: BOOK - Published: 2020-11-03 - Publisher: Springer Nature

The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding
Immunological Aspects of the Liver and Gastrointestinal Tract
Language: en
Pages: 404
Authors: A. Ferguson, R.N.M. MacSween
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to
Immunological Aspects of the Liver and Gastrointestinal Tract
Language: en
Pages: 404
Authors: A. Ferguson, R.N.M. MacSween
Categories: Medical
Type: BOOK - Published: 2012-02-12 - Publisher: Springer

We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to