Neurotransmitter Transporters

Neurotransmitter Transporters

Author: Maarten E. A. Reith

Publisher: Springer Science & Business Media

ISBN: 9781592591589

Category: Medical

Page: 518

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Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.
Neurotransmitter Transporters
Language: en
Pages: 518
Authors: Maarten E. A. Reith
Categories: Medical
Type: BOOK - Published: 2002-05-15 - Publisher: Springer Science & Business Media

Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra-
Cerebral Signal Transduction
Language: en
Pages: 428
Authors: Maarten E. A. Reith
Categories: Medical
Type: BOOK - Published: 2000-02-16 - Publisher: Springer Science & Business Media

Since the pioneering discovery of cyclic AMP four decades ago, a multitude of signaling pathways have been uncovered in which an extracellular signal (first messenger) impacts the cell surface, thereby triggering a cascade that ultimately acts on the cell nucleus. In each cascade the first messenger gives rise to the
Neural Stem Cells for Brain and Spinal Cord Repair
Language: en
Pages: 434
Authors: Tanja Zigova
Categories: Medical
Type: BOOK - Published: 2002-11-05 - Publisher: Springer Science & Business Media

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods
The Neuronal Environment
Language: en
Pages: 432
Authors: Wolfgang Walz
Categories: Medical
Type: BOOK - Published: 2001-12-26 - Publisher: Springer Science & Business Media

Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close
Neural Development and Stem Cells
Language: en
Pages: 468
Authors: Mahendra S. Rao, Mohan C. Vemuri, Melissa Carpenter
Categories: Medical
Type: BOOK - Published: 2007-10-28 - Publisher: Springer Science & Business Media

Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in