Management of Breast Cancer in Older Women

Management of Breast Cancer in Older Women

Author: Malcolm W. Reed

Publisher: Springer

ISBN: 1848002645

Category: Medical

Page: 413

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I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result, she was taking a grand total of 500 mg of capecitabine a day. Yet, her metastatic, ER/PR-negative, Her2-positive breast cancer was undoubtedly responding. Her pain was improving and her chest mass was shrinking, as were her lung metastases... What was the secret of that response? Were Mrs T’s kidneys eli- nating even less drug than predicted by her creatinine clearance? Was her sarcopenia altering drug distribution? Was she absorbing more drug than average? Or was her tumor exquisitely sensitive to fluoropyrimidines? “Physicians,” said Voltaire, “pour drugs they know little for diseases they know even less into patients they know no- ing about.” Medicine has made tremendous progress since the eighteenth century. Yet, there are fields where quite a lot remains to be learned. In developed countries, 25% of breast cancers occur in patients aged 75 years and older. Yet, these patients represent only 4% of the population of traditional clinical trials. That ought to let us wonder how relevant data acquired in patients in their 60s are to a nonagenarian. Fortunately, geriatric oncologists have been stepping up to the task and have gen- ated data to help us to treat such patients.
Management of Breast Cancer in Older Women
Language: en
Pages: 413
Authors: Malcolm W. Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2010-01-12 - Publisher: Springer

I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result,
Management of Breast Cancer in Older Women
Language: en
Pages: 413
Authors: Malcolm W. Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2010-01-18 - Publisher: Springer Science & Business Media

I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result,
Management of Breast Cancer in Older Women
Language: en
Pages: 261
Authors: Malcolm Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2019-05-07 - Publisher: Springer

The second, updated edition of Management of Breast Cancer in Older Women offers the reader evidence-based knowledge to support the care of older patients with breast cancer. It presents the most up-to-date research and clinical practice from leading specialists across a range of fields that come into contact with older
Management of Breast Diseases
Language: en
Pages: 662
Authors: Ismail Jatoi, Achim Rody
Categories: Medical
Type: BOOK - Published: 2016-11-16 - Publisher: Springer

This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, and medical oncologists will find this book useful. The management of breast diseases requires a multidisciplinary approach,
Breast Cancer Management for Surgeons
Language: en
Pages: 731
Authors: Lynda Wyld, Christos Markopoulos, Marjut Leidenius, Elżbieta Senkus-Konefka
Categories: Medical
Type: BOOK - Published: 2017-11-29 - Publisher: Springer

This textbook provides a comprehensive overview of the state of the art knowledge of breast cancer management for the modern breast surgeon. It covers all aspects of multidisciplinary care including primary breast and axillary surgery, reconstruction and oncoplastic techniques, external beam radiotherapy and newer techniques such as tomotherapy, intraoperative radiotherapy