Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research

Author: Steven L. Peterson

Publisher: CRC Press

ISBN: 9781420048889

Category: Mathematics

Page: 272

View: 557

Download Now
There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.
Neuropharmacology Methods in Epilepsy Research
Language: en
Pages: 272
Authors: Steven L. Peterson, Timothy E. Albertson
Categories: Mathematics
Type: BOOK - Published: 2019-05-07 - Publisher: CRC Press

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to
Neuropharmacology Methods in Epilepsy Research
Language: en
Pages: 300
Authors: Taylor & Francis Group
Categories: Mathematics
Type: BOOK - Published: 2020-09-30 - Publisher: CRC Press

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to
Recent Advances in Epilepsy Research
Language: en
Pages: 248
Authors: Devin K. Binder, Helen E. Scharfman
Categories: Medical
Type: BOOK - Published: 2013-03-14 - Publisher: Springer Science & Business Media

Epilepsy research has entered an exciting phase as advances in molecular analysis have supplemented in vitro and in vivo electrophysiologic and phenotypic characterization. Recent Advances in Epilepsy Research sets forth a series of chapter reviews by researchers involved in these advances. This volume is a composite profile of some exciting
Models of Seizures and Epilepsy
Language: en
Pages: 712
Authors: Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé
Categories: Medical
Type: BOOK - Published: 2005-10-04 - Publisher: Elsevier

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30
Screening Methods in Pharmacology
Language: en
Pages: 308
Authors: Robert A. Turner, Peter Hebborn
Categories: Medical
Type: BOOK - Published: 2016-01-26 - Publisher: Elsevier

Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for