Protein Complexes that Modify Chromatin

Protein Complexes that Modify Chromatin

Author: Jerry L. Workman

Publisher: Springer Science & Business Media

ISBN: 9783642557477

Category: Medical

Page: 298

View: 737

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An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.
Protein Complexes that Modify Chromatin
Language: en
Pages: 298
Authors: Jerry L. Workman
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be
Systems Analysis of Chromatin-Related Protein Complexes in Cancer
Language: en
Pages: 316
Authors: Andrew Emili, Jack Greenblatt, Shoshana Wodak
Categories: Medical
Type: BOOK - Published: 2013-08-13 - Publisher: Springer Science & Business Media

​​​​​​​​​​​​​​​​​​​​​​​ Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function
Protein Complexes that Modify Chromatin
Language: en
Pages: 298
Authors: Jerry L. Workman
Categories: Medical
Type: BOOK - Published: 2003-01-08 - Publisher: Springer

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be
Protein Complexes that Modify Chromatin
Language: en
Pages: 298
Authors: Jerry L. Workman
Categories: Medical
Type: BOOK - Published: 2003-01-08 - Publisher: Springer

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be
Protein Complexes that Modify Chromatin
Language: en
Pages: 298
Authors: Jerry L. Workman
Categories: Medical
Type: BOOK - Published: 2003-01-08 - Publisher: Springer

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be