Sinus node inhibitors

Sinus node inhibitors

Author: A. Hjalmarsson

Publisher: Steinkopff

ISBN: 3798508615

Category: Medical

Page: 64

View: 200

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Although surgical and catheter-based revascularization techniques have substan tially improved today's therapeutic potential in ischemic heart disease, in the majority of patients treatment will be conservative for a number of reasons, the cost-effectiveness of non-pharmacological approaches being of major importance. During the last two decades, drug development for ischemic heart disease has been impressive and many new compounds have been added to our therapeutic armamentarium. Nevertheless, where mode of action is concerned, it is interesting to note that, despite all these efforts, we are still confined to three categories of drugs. Antithrombotics and platelet-active agents aside, these concern nitrates, betablocking drugs and calcium antagonists, agents which reduce ischemia by diminishing cardiac work or wall stress,. thereby affecting myocardial oxygen demand and/or by improving coronary blood flow. Alone or in combination, these agents have proved to be efficacious in the treatment of angina pectoris or other symptoms of ischemic heart disease in a number of patients, but certainly not in all. Moreover, as side-effects are often a problem with current antianginal compounds, the physician may find himself restricted in his therapeutic capabilities and in need of new and, preferably, alternative forms of pharmacological treatment.
Sinus node inhibitors
Language: en
Pages: 64
Authors: A. Hjalmarsson, W.J. Remme
Categories: Medical
Type: BOOK - Published: 1991-01-01 - Publisher: Steinkopff

Although surgical and catheter-based revascularization techniques have substan tially improved today's therapeutic potential in ischemic heart disease, in the majority of patients treatment will be conservative for a number of reasons, the cost-effectiveness of non-pharmacological approaches being of major importance. During the last two decades, drug development for ischemic heart
Sinus node inhibitors
Language: en
Pages: 64
Authors: A. Hjalmarsson, W.J. Remme
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Although surgical and catheter-based revascularization techniques have substan tially improved today's therapeutic potential in ischemic heart disease, in the majority of patients treatment will be conservative for a number of reasons, the cost-effectiveness of non-pharmacological approaches being of major importance. During the last two decades, drug development for ischemic heart
Ion Channels and Their Inhibitors
Language: en
Pages: 348
Authors: Satya Prakash Gupta
Categories: Science
Type: BOOK - Published: 2011-06-21 - Publisher: Springer Science & Business Media

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to
Heart Rate Slowing by IF Current Inhibition
Language: en
Pages: 115
Authors: A. John Camm, Micha? Tendera
Categories: Medical
Type: BOOK - Published: 2006-01-01 - Publisher: Karger Medical and Scientific Publishers

This book unfolds the history of the discovery of the transmembrane channel which is responsible for the 'funny' or If current, the primary modulator of heart rate. Inhibition of this current leads to slowing of the heart rate, which is an important component of the successful management of angina pectoris.
Cardiac Drug Development Guide
Language: en
Pages: 431
Authors: Michael K. Pugsley
Categories: Medical
Type: BOOK - Published: 2003 - Publisher: Springer Science & Business Media

A comprehensive survey of the latest therapeutic drug discoveries in cardiac and cardiovascular medicine and of the most recent breakthroughs in molecular cardiology. The authors describe the most advanced procedures in cardiac pharmacology today, including in vivo and in vitro whole animal studies, the electrophysiological methods used to study in