Statistical Issues in Drug Development

Statistical Issues in Drug Development

Author: Stephen S. Senn

Publisher: John Wiley & Sons

ISBN: 9781119238577

Category: Medical

Page: 84

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Statistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more. This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouraging communication between the statistical and life sciences disciplines. In addition to new material on topics like invalid inversion, severity, random effects in network meta-analysis, and explained variation, readers will benefit from the inclusion of: A thorough introduction to basic topics in drug development and statistics, including the role played by statistics in drug development An exploration of the four views of statistics in drug development, including the historical, methodological, technical, and professional An examination of debatable and controversial topics in drug development, including the allocation of treatments to patients in clinical trials, baselines and covariate information, and the measurement of treatment effects Perfect for life scientists and other professionals working in the field of drug development, Statistical Issues in Drug Development is the ideal resource for anyone seeking a one-stop reference to enhance their understanding of the use of statistics during drug development.
Statistical Issues in Drug Development
Language: en
Pages: 84
Authors: Stephen S. Senn
Categories: Medical
Type: BOOK - Published: 2021-08-23 - Publisher: John Wiley & Sons

Statistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands,
Statistical Issues in Drug Development
Language: en
Pages: 456
Authors: Stephen Senn
Categories: Mathematics
Type: BOOK - Published: 1997-10-20 - Publisher: Wiley-Blackwell

"Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. This second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical trials; Expanded sections on missing data, equivalence, meta-analysis and dose finding;
Statistical Issues in Drug Research and Development
Language: en
Pages: 390
Authors: Karl E. Peace
Categories: Mathematics
Type: BOOK - Published: 1989-12-11 - Publisher: CRC Press

This book is a compilation of topics addressed by the ASA Biopharmaceutical Section work groups, including the etiology and evolution of the work groups, the work group guidelines and structure, and the statistical issues associated with clinical trials in clinical drug development programs.
Statistical Issues in Drug Development
Language: en
Pages: 523
Authors: Stephen S. Senn
Categories: Medical
Type: BOOK - Published: 2008-02-28 - Publisher: John Wiley & Sons

Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development
Cross-over Trials in Clinical Research
Language: en
Pages: 364
Authors: Stephen S. Senn
Categories: Mathematics
Type: BOOK - Published: 2003-07-25 - Publisher: John Wiley & Sons

Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more