Virus Dynamics : Mathematical Principles of Immunology and Virology

Virus Dynamics : Mathematical Principles of Immunology and Virology

Author: Martin Nowak

Publisher: Oxford University Press, UK

ISBN: 9780191588518

Category:

Page: 250

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This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature
Virus Dynamics : Mathematical Principles of Immunology and Virology
Language: en
Pages: 250
Authors: Martin Nowak, Robert M. May
Categories:
Type: BOOK - Published: 2000-11-23 - Publisher: Oxford University Press, UK

This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the
Mathematical Immunology of Virus Infections
Language: en
Pages: 245
Authors: Gennady Bocharov, Vitaly Volpert, Burkhard Ludewig, Andreas Meyerhans
Categories: Mathematics
Type: BOOK - Published: 2018-06-12 - Publisher: Springer

This monograph concisely but thoroughly introduces the reader to the field of mathematical immunology. The book covers first basic principles of formulating a mathematical model, and an outline on data-driven parameter estimation and model selection. The authors then introduce the modeling of experimental and human infections and provide the reader
An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology
Language: en
Pages: 177
Authors: James Sneyd, American Mathematical Society
Categories: Medical
Type: BOOK - Published: - Publisher: American Mathematical Soc.

In many respects, biology is the new frontier for applied mathematicians. This book demonstrates the important role mathematics plays in the study of some biological problems. It introduces mathematicians to the biological sciences and provides enough mathematics for bioscientists to appreciate the utility of the modelling approach. The book presents
Case Studies in Systems Biology
Language: en
Pages: 310
Authors: Pavel Kraikivski
Categories: Science
Type: BOOK - Published: 2021-10-06 - Publisher: Springer Nature

This book provides case studies that can be used in Systems Biology related classes. Each case study has the same structure which answers the following questions: What is the biological problem and why is it interesting? What are the relevant details with regard to cell physiology and molecular mechanisms? How
Quantitative Methods for HIV/AIDS Research
Language: en
Pages: 290
Authors: Cliburn Chan, Michael G. Hudgens, Shein-Chung Chow
Categories: Mathematics
Type: BOOK - Published: 2017-08-07 - Publisher: CRC Press

Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory